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mgsR [2018-02-12T10:35:28.000Z]
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mgsR [2018-02-12T10:35:28.000Z]

transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress
Locus
BSU24770
Isoelectric point
9.28
Molecular weight
14.68 kDa
Protein length
126 aa Sequence Blast
Gene length
378 bp Sequence Blast
Function
controls a subset of general stress genes
Product
transcriptional regulator
Essential
no
Synonyms
yqgZ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
  • Lifestyles → Coping with stress → General stress proteins (controlled by SigB)
  • Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress
  • Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

    • Gene

    Coordinates
    2,564,026 → 2,564,406

    The protein

    Catalyzed reaction/ biological activity

  • exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively PubMed

    • Protein family

  • arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily

    • Paralogous protein(s)

  • Spx

    • Modification

  • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed

    • Structure

  • 3L78 (from Streptococcus mutans, 42% identity)

    • Expression and Regulation

    Operons

    Genes
    mgsR
    Description
    PubMed

    Sigma factors

  • SigB: sigma factor, PubMed, in SigB regulon

    • Regulatory mechanism

  • MgsR: activation, in MgsR regulon

    • Regulation

  • induced by stress (SigB) PubMed

    • Additional information

  • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed
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    Biological materials

    Mutant

  • MGNA-C476 (yqgZ::erm), available at the NBRP B. subtilis, Japan
  • BKE24770 (ΔmgsR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTCGTTTTTTCCTCCTCA, downstream forward: _UP4_TGATGAAAAACCGAAGATCC
  • BKK24770 (ΔmgsR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTCGTTTTTTCCTCCTCA, downstream forward: _UP4_TGATGAAAAACCGAAGATCC

    • References

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